My Collie is double MDR1 mutant. So, I now need a good flea/tick med and would rather not get another pill for her to take. , Thanks for the reply! (Theres also a hyperlink to her article.) Happy to be of help! However, not all MLs are created equal, and some are safer than others. Additionally, it can also be given to cats and even pregnant or nursing animals. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! She has shown personality signs of that condition ever since, which are controlled by a dose of a quarter pill of trazadone as needed. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. For Guss veterinarian, Credelio is now the only member of the isoxazoline class that he will sell. According to Dog Aware, most flea and tick control medications have not been found to cause adverse effects when used as directed, but toxicity can occur iftopicalproducts areingested. This is why reading labels is so important. With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Also what can be used for giardia? I would appreciate your comments on Advocate. 1,9 And the fact is, dogs love both chews. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Thank you so much for writing this article!!! Eliminate fleas before they lay eggs. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Freckles my Aussie/Pyr is such a great dog. Is hartz ultraguard ear mite treatment for dogs safe? These people consider it a bad idea to give any Collie a harsh medication such as Heartgard, even if a genetic test reveals a dog to be normal/normal (clear) of the MDR1 gene. I have never even heard of the latter and do not believe they exist in Canada. Im happy to hear you found it helpful! I had never heard of Dimmitrol before, but I did some research after reading your comment. Matching game, word search puzzle, and hangman also available. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. (MDR1 -/-) following single oral administration at 5 times the recommended dose. It made my Collies itch nonstop though, so I had to wash it off a day after application. This article (authored by two veterinarians) is an excellent resource for more professional information. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. (Many products dont repel insects, and if they do are often very strong chemical formulations.). Could you send the link to that article you found? Simparica Trio can be described as a broad-spectrum parasite preventative that offers protection and treatment to dogs. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. thanks for your research. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Simparica TRIO. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. I plan to switch him over to Trifexis also. Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Do you know what the ingredients are in the medicated shampoo? (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. This monthly chewable is recommended for 8 weeks and older dogs, weighing 2.8 lbs or more. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. Key Features of Simparica Trio. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. Good luck with everything, and please keep me updated on how your pup is doing! If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. Fleas can lay up to 1300 eggs within 50 days, 4 but Simparica Trio kills them before they can even lay eggs. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Is Simparica trio safe for dogs with the MDR1 gene? This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. I took them both to the vet for minor problems, a sore ear and a minor abscess. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. Bear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! It was winter. Simparica Trio Dosage. Dogs and cats . ? I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Im glad you found it helpful. Options: 3 flavors. In regard to natural products, Ive used some organic topicals, which Ill list later, that aresomewhat effective as repellents; but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. And use same collar for a few months. Rev. Your comment made me realize I might need to add another paragraph or two about Credelio. Dogs, 6 Month Supply. Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Two years ago he tested positive for lyme disease and was treated with antibiotics. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . My question is about Capstar. Thank you for the research and the detailed info on each product. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Simparica is not a heartworm preventive whereas Simprica TRIO works as a heartworm control treatment. tratados. . While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Giardia can be passed to and cause diarrhea in humans. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. What an awesome article. Australian Shepherds have a slightly lower incidence, with 50% being affected . The oral chew contains a specially optimised trio of ingredients for . The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. Thank you. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Is this true? I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Please help! Is Simparica safe for MDR1 dogs? Thank you for such a great article! My dogs are on Sentinel right now and Frontline Gold. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Id like to thank you so very much for this in depth article. Components Species Test Results Silica colloidal, Ph. I like Frank so much that I had to give him his own story. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. 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